Go Beyond Collagen Stimulation
Biostimulatory effect of RADIESSE® revitalizes the following extracellular matrix (ECM) components:
SUPPORT
Collagen I – Provides the skin with strength and resilience 2-6
STRUCTURE
Collagen III – Delivers structure that simulates remodeling of the ECM2-6
ELASTICITY
Elastin – Recovers the elasticity and firmness of the skin2-6
GLOW
Proteoglycans – Provides hydration and glow2-6
NOURISHMENT
Angiogenesis – Provides long-term sustainability to new tissue2-6

Individual results may vary.
Your Skin Changes Over Time
That’s probably no surprise—but do you know exactly how? Two important components are collagen and elastin, which help keep facial lines and wrinkles at bay. Unfortunately, aging and environmental factors (think sun damage) make it harder for your body to produce collagen and elastin. This can cause facial skin to wrinkle and sag, stealing from your youthful appearance.1,2
CaHA IS KEY
Calcium hydroxylapatite, or CaHA, is what makes RADIESSE® unique as a dermal filler treatment. RADIESSE® is composed of CaHA suspended in an aqueous gel carrier.8
Upon injection, the RADIESSE® CaHA gel matrix provides immediate improvement.8,10,13
CaHA particles form a “scaffold” that stimulates fibroblasts to produce collagen for up to a year and elastin for up to nine months (after only one injection).3,6,9,10
For immediate, long-term rejuvenation1,8,11,13 :
- Immediately smooths wrinkles and folds8,11,13
- Long-term benefit from the stimulation of new collagen and elastin1-5


Renewed Skin Structure
As the gel carrier breaks down, a firm network of collagen fibers form. Then, the formed collagen and elastin replaces the correction provided by the gel carrier, smoothing lines and promoting renewed skin structure.3,6,9
*Stimulation of collagen and elastin occurs when injected into the dermal layer.
RADIESSE® Results
RADIESSE® delivers versatile filling. Whether it’s improvement in the lower face or the hands, RADIESSE® can provide a smooth, natural-looking appearance.3-5,10,11

Have more questions?
Check out these common questions for more info about Radiesse® and what your patients can expect from treatment.