Mechanism of Action

RADIESSE® is an injectable implant composed of smooth calcium hydroxylapatite (CaHA) microspheres (diameter of 25 µm to 45 µm) suspended in a sodium carboxymethylcellulose gel carrier.1 RADIESSE® is approximately 30% CaHA and 70% gel carrier by volume.2

RADIESSE® is injected under the skin in a minimally invasive procedure. Injection of the product provides an immediate and visible correction to the wrinkle. 1

Over time, the gel is absorbed, and fibroblasts appear.3,4 The process of neocollagenesis begins, stimulating the gradual growth of the patient’s own collagen.4,6,9,10 The collagen that forms results in extended correction and increased patient satisfaction. Radiesse builds structural scaffolding by stimulating collagen production for up to 2 years.3,5,6

Histology slides demonstrate deposition of new collagen around CaHA microspheres over an extended period of time. Collagen fibers stain red, while other tissue elements appear more yellow. RADIESSE® stimulates collagen III, which is gradually replaced by collagen I. This creates a stable organized ration of collagen I and II with structure and support, compared to collagen type I stimulation alone.<sup>4-6</sup>
Kyle M C, Robert V, Dale Paul D et al. Neocollagenesis after injection of calcium hydroxylapatite composition in a canine model. Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al] 2008;34 Suppl 1. https://doi.org/10.1111/j.1524-4725.2008.34243.

RADIESSE® stimulates collagen III, which is gradually replaced by collagen I. This creates a stable organized ration of collagen I and II with structure and support, compared to collagen type I stimulation alone.3-5,9,10

  • Collagen III stabilizes and organizes collagen I, ensuring its alignment and thickness8
  • By stimulating both, RADIESSE® results in healthy-looking skin3,5

Collagen I

Collagen III

Elastin

Proteoglycans

Angiogenesis

Key Benefits

Support

Provide the skin with strength and resilience4,6,9,10

Structure

Deliver structure that simulates remodeling of the extracellular matrix (ECM)4,6,9,10

Elasticity

Recover the elasticity and firmness of the skin4,9-11

Glow

Provide hydration and glow11

NOURISH

Provide long-term sustainability to new tissue4,10

Biostimulatory effect of RADIESSE® revitalizes the following extracellular matrix (ECM) components:

The results are immediate, natural, and subtle. The correction is long-lasting but not permanent. Over time, the CaHA microspheres break down and are metabolized by the body’s normal processes.3,7,13

It is important to remember not to overcorrect (overfill) a contour deficiency with RADIESSE® because the depression should gradually improve within several weeks as the treatment effect of RADIESSE® occurs.

How It Works

Become a provider

Contact us if you would like more information about becoming a RADIESSE® provider.

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